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Low-Dose DOACs Increase Risk of Bleeding Episodes
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Prescribers’ efforts to reduce direct oral anticoagulant (DOAC) side effects by lowering dosages appear to be having the opposite effect. A recent study found that atrial fibrillation patients who took low dosages of the blood thinners actually had more bleeding episodes during the first 3 months of treatment, and about 20% showed high blood levels of the medications. Read more.
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Educating MDD Patients on Antidepressant Effectiveness
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The serotonin deficit hypothesis explanation for major depressive disorder (MDD) was widely accepted when new depression drugs first came out, but public sentiment shifted dramatically when research did not find enough evidence for that. Find out how antidepressants actually work, according to a new report, and the best way to explain that to patients to combat distrust.
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Novel Solutions for the ‘Bitter Pill to Swallow’
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Sometimes, overly sweet bubble gum flavor is not enough to combat the bitterness of medications. A new study published in the British Journal of Pharmacology discusses research that might offer a new—and better—solution. Find out how a mouthwash using a novel bitter blocker might be a solution to bitter pills and related nonadherence to medication regimens.
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Paternal Valproate and Its Neurodevelopment Effect on Fetuses
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A report from the European Medicines Agency raised some concerns about the safety of using valproate for men who fathered children. A study of more than 1.2 million children was not able to replicate that, however, and suggests that use of valproate in men does not appear to increase the risk of major congenital and neurodevelopmental disorders, including autism spectrum disorder. Read more.
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