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First-Generation Antihistamines Linked With Increased Seizure Risk
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First-generation antihistamines should be prescribed cautiously to young children. The reason is that those drugs can increase seizure risk by 22%, according to a large new South Korean study published in the Journal of the American Medical Association Network Open. Find out why that might occur and which age groups are most affected.
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Medicare Beneficiaries Increasingly Accept Vaccine Coadministration
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Influenza vaccination rates are high among Medicare beneficiaries, and while many are also vaccinated against COVID-19, coadministration of the two vaccines remains quite low. The vaccination rates are increasing, however, according to a new study published in the American Journal of Preventive Medicine that found the rate rose from about 11% to more than 36% between 2021 and 2022. Read more.
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Do SGLT2i or GLP-1 RAs Better Protect Against Dementia?
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Sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) appear to have neuroprotective effects in patients with type 2 diabetes. A study looked at which of the drug classes provides more protection against dementia. While GLP-1 RAs appear better, the authors caution that the results might be different with the introduction of newer generations in the two drug classes. Read more.
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Drug-Induced QT Interval Prolongation in Heart Failure Patients
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While it is commonly known that heart failure with reduced ejection fraction is a risk factor for drug-induced QT interval prolongation, much less was known about heart failure with preserved ejection fraction. In a recent study, researchers determined that the odds of QT prolongation among inpatients receiving dofetilide or sotalol compared with those who did not have heart failure. Read more.
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