US Pharm. 2014;39(2):14.
Silver Spring, MD—The FDA has recommended that healthcare professionals discontinue prescribing and dispensing prescription combination drug products that contain more than 325 mg of acetaminophen per tablet, capsule, or other dosage unit. There are no available data to show that taking more than 325 mg of acetaminophen per dosage unit provides additional benefit that outweighs the added risks for liver injury. In addition, limiting the amount of acetaminophen will reduce the risk of severe liver injury from inadvertent overdose, which can lead to liver failure, liver transplantation, and even death. Patients may be unaware that many prescription and OTC products contain acetaminophen, making it easy to accidentally overdose.
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